dcbox小金库(中国)

袭荣文 博士

北京科学生命dcbox小金库(中国)资深研究员

Rongwen Xi, Ph.D. Investigator, NIBS, Beijing, China

Phone：010-80726688-8510

Fax： 010-80723249

E-mail：xirongwen@nmamn.com

教育经历

Education

工作经历

Professional Experience

2018-	北京科学生命dcbox小金库(中国)资深研究员 Investigator, National Institute of Biological Sciences, Beijing, China
2011-2018	北京科学生命dcbox小金库(中国)高级研究员 Associate Investigator, National Institute of Biological Sciences, Beijing, China
2006-2011	北京科学生命dcbox小金库(中国)研究员 Assistant Investigator, National Institute of Biological Sciences, Beijing, China
2003-2006	美国思达沃医学dcbox小金库(中国)博士后 Postdoctoral Research Associate with Dr. Ting Xie at the Stowers Institute for Medical Research, USA
1998-2002	美国肯塔基州大学生物系助教，助研 Teaching Assistant, Research Assistant at the Department of Biology,University of Kentucky, USA

研究概述

成体干细胞长期存在于多种组织和器官内，顺利获得不断的自我更新和分化，维持组织细胞的新旧更替。干细胞功能的失调可能导致癌症或退行性病变等疾病的发生，但我们对干细胞增殖和分化时细胞的命运抉择等行为的分子调控机制还没有清楚的理解。我们结合相对简单的遗传模式生物果蝇及哺乳动物模型，以肠道干细胞为主要研究对象，研究干细胞自我更新和多个细胞谱系分化过程中命运决定的内源性机制及环境调控机制，及肠上皮细胞的分化和功能调节机制及它们在脑-肠-肠道菌群轴中所扮演的角色。我们的研究将最终为肠道肿瘤、代谢性疾病等肠道相关疾病的防治给予理论依据和试验基础。

Research Description

Publications:

1. Zhu G, Hu J, Xi R* (2021). The dcbox小金库(中国)ular niche for intestinal stem dcbox小金库(中国)s: a team effort. dcbox小金库(中国) Regen. 10(1):1.

2. Shi J, Jin Z, Yu Y, Zhang Y, Yang F, Huang H, Cai T, Xi R* (2021). A Progressive Somatic dcbox小金库(中国) Niche Regulates Germline Cyst Differentiation in the Drosophila Ovary. Curr Biol. 31(4):840-852.e5.

3. Jin Z, Chen J, Huang H, Wang J, Lv J, Yu M, Guo X, Zhang Y, Cai T, Xi R*(2020). The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level. dcbox小金库(中国) Rep. 31(8):107683.

4. Kobayashi M, Lin Y, Mishra A, Shelly C, Gao R, Reeh CW, Wang PZ, Xi R, Liu Y, Wenzel P, Ghosn E, Liu Y, Yoshimoto M (2020). Bmi1 Maintains the Self-Renewal Property of Innate-like B Lymphocytes. J Immunol. 204(12):3262-3272.

5. Li Z, Guo X, Huang H, Wang C, Yang F, Zhang Y, Wang J, Han L, Jin Z, Cai T, Xi R*(2020). A Switch in Tissue Stem dcbox小金库(中国) Identity Causes Neuroendocrine Tumors in Drosophila Gut. dcbox小金库(中国) Rep. 30(6):1724-1734.e4.

6. Guo X, Yin C, Yang F, Zhang Y, Huang H, Wang J, Deng B, Cai T, Rao Y, Xi R* (2019). The dcbox小金库(中国)ular Diversity and Transcription Factor Code of Drosophila Enteroendocrine dcbox小金库(中国)s. dcbox小金库(中国) Rep. 29(12):4172-4185.e5.

7. Guo X, Huang H, Yang Z, Cai T, Xi R*  (2019). Division of Labor: Roles of Groucho and CtBP in Notch-Mediated Lateral Inhibition that Controls Intestinal Stem dcbox小金库(中国) Differentiation in Drosophila. Stem dcbox小金库(中国) Reports. 12(5):1007-1023

8. Yang F*, Quan Z, Huang H, He M, Liu X, Cai T, and Xi R* (2019). Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing. Elife 2019 Jan 16;8. pii: e40806.

9. Zhang W, Zhang X, Xue Z, Li Y, Ma Q, Ren X, Zhang J, Yang S, Yang L, Wu M, Ren M, Xi R, Wu Z, Liu JL, Matunis E, Dai J, Gao G (2018). Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants. Dev dcbox小金库(中国). pii: S1534-5807(18)31031-1.

10. Chen J, Xu N, Wang C, Huang P, Huang H, Jin Z, Yu Z, Cai T, Jiao R, Xi R* (2018). Transient Scute activation via a self-stimulatory loop directs enteroendocrine dcbox小金库(中国) pair specification from self-renewing intestinal stem dcbox小金库(中国)s. Nat dcbox小金库(中国) Biol. 20(2):152-161

11. Yin C, Xi R* (2018). A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem dcbox小金库(中国) Enteroendocrine Commitment in Drosophila. Stem dcbox小金库(中国) Reports. 9;10(1):43-57.

12. Huang C, Yang F, Zhang Z, Zhang J, Cai G, Li L, Zheng Y, Chen S, Xi R*, Zhu B* (2017). Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila. Nat Commun. 8(1):1649.

13. Liu X, Wei W, Li X, Shen P, Ju D, Wang Z, Zhang R, Yang F, Chen C, Cao K, Zhu G, Chen H, Chen L, Sui J, Zhang E, Wu K, Wang F, Zhao L, Xi R* (2017). BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3. Gastroenterology. pii: S0016-5085(17)35976-0.

14. Li Y*, Pang Z, Huang H, Wang C, Cai T, Xi R* (2017). Transcription Factor Antagonism Controls Enteroendocrine dcbox小金库(中国) Specification from Intestinal Stem dcbox小金库(中国)s. Sci Rep. 20;7(1):988.

15. Yang F, Xi R* (2017). Silencing transposable elements in the Drosophila germline. dcbox小金库(中国) Mol Life Sci. 74(3):435-448.

16. Chen J., Li J., Huang H. and Xi R*. (2016). Gene Expression Analysis of Sorted dcbox小金库(中国)s by RNA-seq in Drosophila Intestine. Bio-protocol 6(24): e2079. DOI: 10.21769/BioProtoc.2079

17. Li X, Yang F, Chen H, Deng B, Li X, Xi R* (2016). Control of germline stem dcbox小金库(中国) differentiation by polycomb and trithorax group genes in the niche microenvironment. Development. 143(19):3449-3458 pii: dev.137638.

18. Chen J, Xu N, Huang H, Cai T, Xi R* (2016). A feedback amplification loop between stem dcbox小金库(中国)s and their progeny promotes tissue regeneration and tumorigenesis. Elife. 5. pii: e14330. doi: 10.7554/eLife.14330

19. Wang C, Xi R* (2015). Keeping intestinal stem dcbox小金库(中国) differentiation on the Tramtrack. Fly (Austin). 14:0.

20. Hu Z, Hu Y, Liu X, Xi R, Zhang A, Liu D, Xie Q, Chen L (2015). Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor. Oncotarget. 6(31):31628-39

21. Wang C, Guo X, Dou K, Chen H, Xi R* (2015). Ttk69 acts as a master repressor of enteroendocrine dcbox小金库(中国) specification in Drosophila intestinal stem dcbox小金库(中国) lineages. Development 142(19):3321-31

22. Yang F, Zhao R, Fang X, Huang H, Xuan Y, Ma Y, Chen H, Cai T, Qi Y, Xi R* (2015). The RNA surveillance complex Pelo-Hbs1 is required for transposon silencing in the Drosophila germline. EMBO Rep. 16(8):965-74

23. Wang C, Guo X, Xi R* (2014). EGFR and Notch signaling respectively regulate proliferative activity and multiple dcbox小金库(中国) lineage differentiation of Drosophila gastric stem dcbox小金库(中国)s. dcbox小金库(中国) Research 24(5):610-27

24. Quan Z, Sun P, Lin G, Xi R* (2013). TSC1/2 regulates intestinal stem dcbox小金库(中国) maintenance and lineage differentiation via Rheb-TORC1-S6K but independent of nutrition status or Notch regulation. J dcbox小金库(中国) Sci. 126:3884-92

25. Wang C, Zhao R, Huang P, Yang F, Quan Z, Xu N, Xi R* (2013). APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression. Developmental Biology 378(2):122-40

26. Lin G, Zhang X, Ren J, Pang Z, Wang C, Xu N, Xi R* (2013). Integrin signaling is required for maintenance and proliferation of intestinal stem dcbox小金库(中国)s in Drosophila. Developmental Biology 377(1):177-87

27. Wen P, Quan Z, Xi R* (2012). The biological function of the WD40 repeat-containing protein p55/Caf1 in Drosophila. Developmental Dynamics 241(3):455-64

28. Xu N, Wang SQ, Tan D, Gao Y, Lin G, Xi R* (2011). EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem dcbox小金库(中国)s. Developmental Biology 354(1):31-43

29. Su Y, Deng B, Xi R* (2011). Polycomb group genes in stem dcbox小金库(中国) self-renewal: a double-edged sword. Epigenetics. 6(1):16-9.

30. Sun P, Quan Z, Zhang, B, Wu T, Xi R* (2010). TSC1/2 tumour suppressor complex maintains Drosophila germline stem dcbox小金库(中国)s by preventing differentiation. Development 137(15):2461-9

31. Wen P, Sun P, Xi R* (2010). Stem dcbox小金库(中国) niche (book chapter) in “Regenerative Medicine – From Protocol to Patient”. The Springer Press.

32. Li X, Han Y, Xi R* (2010). Polycomb group genes Psc and Su(z)2 restrict follicle stem dcbox小金库(中国) self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling. Genes & Development 24(9):933-46.

33. Zhao R, Xi R* (2010). Stem dcbox小金库(中国) Competition for Niche Occupancy: Emerging Themes and Mechanisms. Stem dcbox小金库(中国) Rev. 6(3):345-50

34. Lin G, Xu N, Xi R* (2010). Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem dcbox小金库(中国)s. J Mol dcbox小金库(中国) Biol 2(1): 37-49.

35. Xi, R* (2009). Anchoring stem dcbox小金库(中国)s in the niche by dcbox小金库(中国) adhesion molecules. dcbox小金库(中国) Adh Migr 3(4): 396-401.

36. Lin G, Xi R* (2008) Intestinal stem dcbox小金库(中国), muscular niche and wingless signaling. Fly (Austin). 2(6): 310-2.

37. Lin G, Xu N, Xi R* (2008). Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem dcbox小金库(中国)s. Nature 455(7216):1119-23.

38. Zhao R, Xuan Y, Li X, Xi R* (2008). Age-related changes of germline stem dcbox小金库(中国) activity, niche signaling activity and egg production in Drosophila. Aging dcbox小金库(中国) 7(3):344-54

39. Xi R, Xie T (2005). Stem dcbox小金库(中国) self-renewal controlled by chromatin remodeling factors. Science 310(5753):1487-9.

40. Xi R, Doan C, Liu D, Xie T (2005). Pelota controls self-renewal of germline stem dcbox小金库(中国)s by repressing a bam-independent differentiation pathway. Development 132(24):5365-74.

41. Xi R, Kirrily D, Xie T (2005). Molecular mechanisms controlling germline and somatic stem dcbox小金库(中国)s: similarities and differences (review). Curr Opin Genet Dev. 15(4):381-7.

42. Rawlings JS, Rennebeck G, Harrison SM, Xi R, Harrison DA (2004). Two Drosophila Suppressors of Cytokine Signaling (SOCS) differentially regulate JAK and EGFR pathway activities. BMC dcbox小金库(中国) Biol. 15;5(1):38.

43. Song X, Wong, MD, Kawase E, Xi R, Ding BC, McCarthy J, Xie T (2004). BMP signaling from the niche directly represses the transcription of a differentiating gene, bag of marbles, in the germline stem dcbox小金库(中国)s of Drosophila ovary. Development 131(6):1353-64.

44. Xi R, McGregor JR, Harrison DA (2003). A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium. Developmental dcbox小金库(中国) 4(2):167-77.

45. McGregor JR, Xi R, Harrison DA (2002). JAK signaling is somatically required for follicle dcbox小金库(中国) differentiation in Drosophila. Development 129(3):705-17.